Spontaneous superimposed preeclampsia: chronology and expression unveiled by temporal transcriptomic analysis.

ABSTRACT: Preeclampsia (PE), a multifactorial pregnancy-specific syndrome accounting for up to 8% of pregnancy complications, is a leading cause of maternal and fetal morbidity and mortality. PE is also associated with long-term risk of hypertension and stroke for both mother and fetus. Currently, the only "cure" is delivery of the baby and placenta, largely because the pathogenesis of PE is not yet fully understood. PE is associated with impaired vascular remodeling at the maternal-fetal interface and placental insufficiency; however, specific factors contributing to this impairment have not been identified. To identify molecular pathways involved in PE, we examined temporal transcriptomic changes occurring within the uterus, uterine implantation sites, and placentae from the Dahl salt-sensitive (D

SUBMITTER: Maeda KJ 

PROVIDER: S-EPMC6732412 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature