Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages.

ABSTRACT: Atrial fibrillation is a significant worldwide contributor to cardiovascular morbidity and mortality. Few studies have investigated the differences in gene expression between the left and right atrial appendages, leaving their characterization largely unexplored. In this study, differential gene expression was investigated in atrial fibrillation and sinus rhythm using left and right atrial appendages from the same patients. RNA sequencing was performed on the left and right atrial appendages from five sinus rhythm (SR) control patients and five permanent AF case patients. Differential gene expression in both the left and right atrial appendages was analyzed using the Bioconductor package edgeR. A selection of differentially expressed genes, with relevance to atrial fibrillation, were furth

SUBMITTER: Thomas AM 

PROVIDER: S-EPMC6732415 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature