MicroRNA-126: a promising biomarker for angiogenesis of diabetic wounds treated with negative pressure wound therapy.

ABSTRACT:

Background

Negative pressure wound therapy represents an effective therapy to treat nonhealing diabetic wounds by promoting angiogenesis, of which the mechanism hasn't been investigated thoroughly. Growing evidence suggests that miRNAs hold great potential to be clinical biomarkers, and miR-126 is an essential angiogenesis regulator in diabetic wound repair.

Purpose

Our study aims to explore the effect of NPWT on the expression of miR-126 in the wound tissue and plasma of diabetic rat models and the association between circulating miR-126 and two quantitative indexes of angiogenesis.

Methods

Full-thickness excisional wounds were created on the back of diabetic rats. Measure the wound closure and collect the wound tissue and blood for H&E, immunohistochemistry, Western

SUBMITTER: Zhang D 

PROVIDER: S-EPMC6732575 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature