Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer.

ABSTRACT:

Background

Many epidemiological studies have shown that vitamin D deficiency is associated with various types of human cancers. The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). The VDR gene is highly expressed in the colon and is involved in many biological functions. The aim of the current study was to assess the relationship between serum vitamin D metabolite and calcium levels with VDR polymorphisms in normal and colorectal cancer (CRC) patients.

Methods

Fifty Saudi CRC patients and fifty controls were enrolled in the study. The levels of total vitamin D, 25(OH)D₃, and calcium were measured in serum.

Results

The homozygous genotype (aa) of the ApaI VDR polymorphi

SUBMITTER: Al-Ghafari AB 

PROVIDER: S-EPMC6732607 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature