The chloroplast and mitochondrial C-to-U RNA editing in Arabidopsis thaliana shows signals of adaptation.

ABSTRACT: C-to-U RNA editing is the conversion from cytidine to uridine at RNA level. In plants, the genes undergo C-to-U RNA modification are mainly chloroplast and mitochondrial genes. Case studies have identified the roles of C-to-U editing in various biological processes, but the functional consequence of the majority of C-to-U editing events is still undiscovered. We retrieved the deep sequenced transcriptome data in roots and shoots of Arabidopsis thaliana and profiled their C-to-U RNA editomes and gene expression patterns. We investigated the editing level and conservation pattern of these C-to-U editing sites. The levels of nonsynonymous C-to-U editing events are higher than levels of synonymous events. The fraction of nonsynonymous editing sites is higher than neutral expectation. Hi

SUBMITTER: Chu D 

PROVIDER: S-EPMC6732656 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature