Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer.

ABSTRACT: Tumor metastasis and anticancer drug resistance are the major causes of mortality in patients with colorectal cancer (CRC). Due to the limitations of conventional biomarkers, it is urgent to identify novel and valid biomarkers to predict the progression and prognosis of CRC. Reverse transcription-quantitative polymerase chain reaction and western blotting were used to detect MAGT1 expression in CRC clinical samples or cell lines. Bioinformatics analysis was used to investigate the association between MAGT1 alteration and clinicopathological features of patients with CRC. The present study revealed that the transcription levels of magnesium transporter 1 (MAGT1) were significantly increased in CRC tissues compared with matched adjacent normal tissues. Overexpression of MAGT1 was associated

SUBMITTER: Zheng K 

PROVIDER: S-EPMC6732944 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature