Identification of candidate genes associated with the pathogenesis of small cell lung cancer via integrated bioinformatics analysis.

ABSTRACT: The pathogenesis of small cell lung cancer (SCLC), a highly metastatic malignant tumor, remains unclear. In the present study, important genes and pathways that are involved in the pathogenesis of SCLC were identified. The following four datasets were downloaded from the Gene Expression Omnibus: GSE60052, GSE43346, GSE15240 and GSE6044. The differentially expressed genes (DEGs) between the SCLC samples and the normal samples were analyzed using R software. The limma package was used for every dataset. The RobustRankAggreg package was used to integrate the DEGs from the four datasets. Functional and pathway enrichment analyses were conducted using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases with FunRich software and R software, respectively. In addition, the prot

SUBMITTER: Liao Y 

PROVIDER: S-EPMC6732946 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature