Dysregulation of N⁶-methyladenosine regulators predicts poor patient survival in mantle cell lymphoma.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m⁶A during B-cell development and B-cell tumorigenesis remains poorly understood. By analyzing the gene expression profile of 123 mantle cell lymphoma cases from the Gene Expression Omnibus database, the present study demonstrated that one-half of the m⁶A regulators were able to predict patient survival in mantle cell lymphoma, notably the m⁶A.index. The expression levels of the m⁶A regulators were regarded as good classifiers in mantle cell lymphoma. The m⁶A.index-low mantle cell lymphoma

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6732954 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature