Identifying prognosis and metastasis-associated genes associated with Ewing sarcoma by weighted gene co-expression network analysis.

ABSTRACT: Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (OVS) and metastasis in ES. Traditional methods for identifying differentially expressed genes lack the in-depth information of mechanistic studies. In this study, a weighted co-expression network for ES was constructed through weighted gene co-expression network analysis to identify co-expression modules associated with clinical phenotypes. The hub genes in the metastasis- and OVS-related co-expression modules were extracted, and the association between the hub genes and patien

SUBMITTER: Wang B 

PROVIDER: S-EPMC6732955 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature