Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma.

ABSTRACT: Lung squamous cell carcinoma (LSCC) exhibits a number of similarities with lung adenocarcinoma (LA) in terms of copy number alterations. However, compared with LA, the range of genetic alterations in LSCC is less understood. In the present study, a large-scale literature-based search of LA-associated genes and LSCC-associated genes was performed to identify the genetic basis in common with these two diseases. For each of the LA-associated genes, a mega-analysis was performed to test its expression variations in LSCC using 11 RNA expression datasets, with significant genes identified using statistical analysis. Subsequently, a functional pathway analysis was performed to identify a possible association between any of the significant genes identified from the mega-analysis and LSCC, followed

SUBMITTER: Zhang G 

PROVIDER: S-EPMC6732964 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature