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Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8⁺ T cells compared with women with BRCA wild-type disease during the early disease course.

ABSTRACT: Immunosuppressive myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are associated with immunologic tolerance and poor prognosis in ovarian cancer (OvCa). We hypothesized that women with germline BRCA1 and BRCA2 mutation-associated (gBRCAm) OvCa would have fewer circulating immunosuppressive immune cells compared to those with BRCA wild-type (BRCAwt) disease during their early disease course (<5 years post-diagnosis) where gBRCAm is a favorable prognostic factor. We collected and viably froze peripheral blood mononuclear cells (PBMCs) from patients with recurrent OvCa olaparib clinical trials (NCT01445418/NCT01237067). Immune subset analyses were performed using flow cytometry for Tregs, exhausted CD8⁺ T cells, monocytes and MDSCs. Functional marker express

SUBMITTER: Lee JM

PROVIDER: S-EPMC6732977 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8⁺ T cells compared with women with BRCA wild-type disease during the early disease course.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8⁺ T cells compared with women with BRCA wild-type disease during the early disease course.