Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory.

ABSTRACT: Epigenetic modifications and regulators represent potential molecular elements which control relevant physiological and pathological features, thereby contributing to the natural history of human disease. These epigenetic modulators can be employed as disease biomarkers, since they show several advantages and provide information about gene function, thus explaining differences among patient endophenotypes. In addition, epigenetic biomarkers can incorporate information regarding the effects of the environment and lifestyle on health and disease, and monitor the effect of applied therapies. Technologies used to analyze these epigenetic biomarkers are constantly improving, becoming much easier to use. Laboratory professionals can easily acquire experience and techniques are becoming more affo

SUBMITTER: Garcia-Gimenez JL 

PROVIDER: S-EPMC6733278 | biostudies-literature | 2017 Nov - Dec

REPOSITORIES: biostudies-literature