CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population.

ABSTRACT:

Introduction

Chronic obstructive pulmonary disease (COPD) is a lung disease closely related to exposure to exogenous substances. CYP2B6 can activate many exogenous substances, which in turn affect lung cells. The aim of this study was to assess the association of single-nucleotide polymorphisms (SNPs) in CYP2B6 with COPD risk in a Chinese Han population.

Materials and methods

Genotypes of the five candidate SNPs in CYP2B6 were identified among 318 cases and 508 healthy controls with an Agena MassARRAY method. The association between CYP2B6 polymorphisms and COPD risk was evaluated using genetic models and haplotype analyses.

Results

In allele model, we observed that rs4803420 G and rs1038376 A were related to COPD risk. And rs4803420 G/T an

SUBMITTER: Ding Y 

PROVIDER: S-EPMC6733340 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature