Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia.

ABSTRACT:

Objective

The aim of this study was to identify the active anti-ischemic components of Pterocypsela elata (P. elata) using a network pharmacology approach to construct an effective component anti-cerebral ischemic target network and systematically analyze this medicinal material.

Methods

Pharmacological studies have shown that P. elata has an obvious effect against cerebral ischemia. To identify the potential targets, 14 components of P. elata were docked to each structural element of the targets in the DRAR-CPI database by reverse docking technology. We then compared the identified potential targets with FDA-approved targets for stroke/cerebral infarction treatment in the DrugBank database and identified the active components of P. elata a

SUBMITTER: Niu B 

PROVIDER: S-EPMC6733351 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature