Association of Serum Paraoxonase/Arylesterase Activity With All-Cause Mortality in Maintenance Hemodialysis Patients.

ABSTRACT:

Context

In end-stage renal disease (ESRD), serum high-density lipoprotein cholesterol (HDL-C) level is not an accurate predictor of mortality, partly because it does not necessarily correlate with indices of HDL function. Paraoxonase (PON) is a major enzyme constituent of HDL and a key component of HDL antioxidant activity. Apolipoprotein A-I (Apo A-1) is the core HDL structural protein that plays a major role in various aspects of HDL function.

Objective

We sought to examine PON activity and Apo A-I levels in patients with ESRD vs healthy controls.

Design and setting

PON/arylesterase activity was measured in 499 patients with maintenance hemodialysis (MHD) and 24 healthy controls with similar distributions of age, sex, and race/ethnicity. Serum acrolein-modified Apo

SUBMITTER: Suematsu Y 

PROVIDER: S-EPMC6733492 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature