Genomic and Transcriptomic Characterization of Papillary Microcarcinomas With Lateral Neck Lymph Node Metastases.

ABSTRACT:

Context

Most papillary microcarcinomas (PMCs) are indolent and subclinical. However, as many as 10% can present with clinically significant nodal metastases.

Objective and design

Characterization of the genomic and transcriptomic landscape of PMCs presenting with or without clinically important lymph node metastases.

Subjects and samples

Formalin-fixed paraffin-embedded PMC samples from 40 patients with lateral neck nodal metastases (pN1b) and 71 patients with PMC with documented absence of nodal disease (pN0).

Outcome measures

To interrogate DNA alterations in 410 genes commonly mutated in cancer and test for differential gene expression using a custom NanoString panel of 248 genes selected primarily based on their association with tumor size and nodal disease

SUBMITTER: Perera D 

PROVIDER: S-EPMC6733494 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature