Ontology highlight
ABSTRACT:
SUBMITTER: Langan RA
PROVIDER: S-EPMC6733528 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature 20190724 7768
Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable protein systems de novo, through the modulation of competing inter- and intramolecular interactions. We design a static, five-helix 'cage' with a single interface that can interact either intramolecularly with a terminal 'latch' helix or intermo ...[more]