Metrics and Acquisition Modes for Fixation Stability as a Visual Function Biomarker.

ABSTRACT:

Purpose

To compare different metrics and acquisition modes of fixation stability as a new visual function biomarker in a large cohort of patients with ABCA4-related Stargardt disease from the multicenter prospective ProgStar study.

Methods

Fixation was tested during a separate fixation exam and also dynamically during a sensitivity exam, using fundus-tracking microperimetry (Nidek MP-1). Fixation data were analyzed using the bivariate contour ellipse area (BCEA), the 2/4 degree method, and the Fujii classification.

Results

In a total of 235 patients, the mean BCEA was larger when measured during the sensitivity exam (418 eyes; 12.5 vs. 4.6 deg2 during the fixation task in 427 eyes). Correlations between the two tests were generally weak. Fixation stability during the

SUBMITTER: Schonbach EM 

PROVIDER: S-EPMC6733530 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature