Proteomic Alterations in Aqueous Humor From Patients With Primary Open Angle Glaucoma.

ABSTRACT:

Purpose

Primary open angle glaucoma (POAG) is the most prevalent form of glaucoma, accounting for approximately 90% of all cases. The aqueous humor (AH), a biological fluid in the anterior and posterior chambers of the eye, is involved in a multitude of functions including the maintenance of IOP and ocular homeostasis. This fluid is very close to the pathologic site and is also known to have a significant role in glaucoma pathogenesis. The purpose of this study was to identify proteomic alterations in AH from patients with POAG.

Methods

AH samples were extracted from 47 patients undergoing cataract surgery (controls: n = 32; POAG: n = 15). Proteomic analysis of the digested samples was accomplished by liquid-chromatography-mass spectrometry. The identified proteins were eval

SUBMITTER: Sharma S 

PROVIDER: S-EPMC6733532 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature