TRPM8 channel activation triggers relaxation of pudendal artery with increased sensitivity in the hypertensive rats.

ABSTRACT:

Introduction

Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the function of cold-sensing TRPM8 channel in internal pudendal artery (IPA) in both normotensive and hypertensive rats.

Methods

We performed experiments integrating physiological, pharmacological, biochemical and cellular techniques.

Results

TRPM8 channels are expressed in the IPA and in vascular smooth muscle cells from IPA. In addition, TRPM8 activation, by both a cooling compound icilin (82.1 ± 3.0%, n = 6) and cold temperature [thermal stimulus, basal tone

SUBMITTER: Silva DF 

PROVIDER: S-EPMC6733625 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature