Process of selecting and educating HCV-uninfected kidney waiting-list candidates for HCV-infected kidney transplantation.

ABSTRACT: Long waiting times for kidney transplant (KT) and the high risk of mortality on dialysis have prompted investigation into strategies to utilize hepatitis C virus (HCV)-infected organs to decrease discard rates of potentially viable kidneys. Due the opioid epidemic, the number of HCV-infected donors has increased significantly. With the development of direct-acting antiviral therapies for HCV infection, now more than 95% of patients who received treatment are cured. Experimental trials have used direct-acting antiviral therapy to treat HCV infection in HCV-uninfected transplant recipients of kidneys from HCV-viremic donors. To date, HCV has been eradicated in all cases. Though these strategies will potentially increase the donor pool of available kidneys, shorten waitlist times, and ultimat

SUBMITTER: Sise ME 

PROVIDER: S-EPMC6733639 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature