Molecular analysis of V617F mutation in Janus kinase 2 gene of breast cancer patients.

ABSTRACT:

Background

Breast cancer is a multifactorial disease with the highest frequency in females. Genetic and environmental factors can cause mutation in several genes like tyrosine kinase, JAK2 gene which may initiate cancer. Molecular analysis of mutations in the JAK2 gene along with determination of environmental, clinical and haematological risk factors associated with breast cancer patients is need of hour to improve patient's healthcare. Somatic JAK2 valine-to-phenylalanine (617 codon) mutation is one of the widely prevalent mutations.

Methods

Blood was collected from seventy breast cancer patients after their consent. The questionnaire included risk factors, age group, locality, number of children, tumor type, family history, time of initial diagnosis, no of cycles/m

SUBMITTER: Karim S 

PROVIDER: S-EPMC6733781 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature