Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.

ABSTRACT: Hand grip strength is a measure of muscular strength and is used to study age-related loss of physical capacity. In order to explore the biological mechanisms that influence hand grip strength variation, an epigenome-wide association study (EWAS) of hand grip strength in 672 middle-aged and elderly monozygotic twins (age 55-90 years) was performed, using both individual and twin pair level analyses, the latter controlling the influence of genetic variation. Moreover, as measurements of hand grip strength performed over 8 years were available in the elderly twins (age 73-90 at intake), a longitudinal EWAS was conducted for this subsample. No genome-wide significant CpG sites or pathways were found, however two of the suggestive top CpG sites were mapped to the COL6A1 and CACNA1B genes, know

SUBMITTER: Soerensen M 

PROVIDER: S-EPMC6733812 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature