The fine-tuning of endoplasmic reticulum stress response and autophagy activation during trophoblast syncytialization.

ABSTRACT: The syncytiotrophoblast (STB) is a multinuclear layer forming the outer surface of the fetal part of the placenta deriving from villous cytotrophoblastic cell (vCTB) fusion and differentiation. This syncytialization process is characterized by morphological and biochemical alterations of the trophoblast, which probably require removal of pre-existing structures and proteins to maintain cell homeostasis and survival. Interestingly, autophagy, which allows degradation and recycling of cellular components, was shown to be activated in syncytiotrophoblast. Here we examined the involvement of endoplasmic reticulum stress (ERS) response in autophagy activation during vCTB syncytialization. We first demonstrated the activation of ERS response and autophagy during the time course of trophoblastic

SUBMITTER: Bastida-Ruiz D 

PROVIDER: S-EPMC6733854 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature