Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis.

ABSTRACT: Pulmonary fibrosis is characterized by the remodeling of fibrotic tissue and collagen deposition, which mainly results from aberrant fibroblasts proliferation and trans-differentiation to myofibroblasts. Patients with chronic myelogenous leukemia, myeloproliferative disorder, and scleroderma with pulmonary fibrosis complications show megakaryocyte infiltration in the lung. In this study, we demonstrated that the number of CD41⁺ megakaryocytes increased in bleomycin (BLM)-induced lung fibrosis tissues through the Chemokine (CXCmotif) ligand 12/Chemokine receptor 4 (CXCL12/CXCR4) axis. Pharmacological inhibition of the CXCL12/CXCR4 axis with WZ811 prevented migration of CD41⁺ megakaryocytes induced by BLM-injured lung tissue ex vivo and in vivo. In addition, WZ811 signi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6733875 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature