Time-dependent infarct volume affects the benefit of recanalization.

ABSTRACT:

Objectives

The benefit threshold of infarct volume from recanalization remains unclear. We assumed that the threshold decreased over time, and then investigated the benefit curve of infarct volume during different time periods.

Methods

We reviewed prospectively collected clinical and imaging data from acute ischemic stroke patients with internal carotid artery and M1 occlusion who underwent angiography before and 24 h after reperfusion therapy. Ordinal analyses of modified Rankin Scale scores were performed and curves were fitted.

Results

Of the included 445 patients, the median age was 71 years and 157 (35.3%) were women. The mean time from onset to treatment (OTT) was 248 ± 142 min. The median baseline infarct core volume was 49 (IQR 22-85) ml. Follow-up angiography

SUBMITTER: Hu H 

PROVIDER: S-EPMC6734046 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature