Virulence of new variant strains of Clostridium difficile producing only toxin A or binary toxin in the hamster model.

ABSTRACT: Pathogenesis of Clostridium difficile has been linked to production of toxins, including the large toxins A and B as well as the binary toxin CDT. Until recently, toxin A was only found in combination in clinical strains with the toxin B, unlike toxin B or CDT, which were found alone in toxigenic variants. New toxigenic variants of C. difficile detected in our laboratory from patients with diarrhoea or severe colitis, including a variant producing only toxin A, were tested for virulence in the hamster model, which displays the clinical features of C. difficile disease. Hamsters infected with a strain producing only toxin B induced similar clinical signs, time to death from infection and histologic damage compared to the hypervirulent strain 027. No mortality or clinica

SUBMITTER: Marvaud JC 

PROVIDER: S-EPMC6734109 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature