A study of the role of DIO1 and DIO2 polymorphism in thyroid cancer and drug response to therapy in the Saudi population.

ABSTRACT:

Background

Deiodinases comprise a group of selenoproteins that regulate the bioavailability of active thyroid hormones (TH) in a time and tissue specific fashion. They increase the hormonal activity by metabolizing their inactive precursors to active forms or terminate their activity by deactivating active hormones. The role of the deiodinase (DIO) gene polymorphisms in thyroid cancer is not fully understood yet. This study evaluated the potential association of the DIO1 and DIO2 genes with differentiated thyroid cancer and differential thyroxine dose requirement in thyroidectomized patients in a Saudi cohort.

Methods

We selected four variants (one DIO1 and three DIO2) for the association studies using Taqman assays in 507 DTC patients unde

SUBMITTER: AlRasheed MM 

PROVIDER: S-EPMC6734157 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature