Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.

ABSTRACT:

Background

Inflammatory response during urinary tract infection (UTI) is mediated by innate immune defense. Nod like receptors (NLRs) have been proposed to work simultaneously beside TLR pathways to mediate pro-inflammatory response and maintain tissue homeostasis. Some in vitro reports have showed the involvement of NLRP3 inflammasome during uropathogenic Escherichia coli (UPEC) mediated UTI. So we have sought to determine the status of various inflammasomes and their components in UPEC mediated UTI.

Methods

A total of 186 females experiencing the first episode of UTI were recruited for the study and forty were found to be positive for UPEC (≥10⁵ CFU/ml) in their urine (N = 40). Further, we analyzed the expression of NLRP3, N

SUBMITTER: Verma V 

PROVIDER: S-EPMC6734172 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature