Cannabinoid receptor-mediated modulation of inhibitory inputs to mitral cells in the main olfactory bulb.

ABSTRACT: The endocannabinoid (eCB) signaling system has been functionally implicated in many brain regions. Our understanding of the role of cannabinoid receptor type 1 (CB₁) in olfactory processing remains limited. Cannabinoid signaling is involved in regulating glomerular activity in the main olfactory bulb (MOB). However, the cannabinoid-related circuitry of inputs to mitral cells in the MOB has not been fully determined. Using anatomical and functional approaches we have explored this question. CB₁ was present in periglomerular processes of a GAD65-positive subpopulation of interneurons but not in mitral cells. We detected eCBs in the mouse MOB as well as the expression of CB₁ and other genes associated with cannabinoid signaling in the MOB. Patch-clamp electrop

SUBMITTER: Wang ZJ 

PROVIDER: S-EPMC6734407 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature