Novel hypotheses emerging from GWAS in migraine?

ABSTRACT: Recent technical advances in genetics made large-scale genome-wide association studies (GWAS) in migraine feasible and have identified over 40 common DNA sequence variants that affect risk for migraine types. Most of the variants, which are all single nucleotide polymorphisms (SNPs), show robust association with migraine as evidenced by the fact that the vast majority replicate in subsequent independent studies. However, despite thorough bioinformatic efforts aimed at linking the migraine risk SNPs with genes and their molecular pathways, there remains quite some discussion as to how successful this endeavour has been, and their current practical use for the diagnosis and treatment of migraine patients. Although existing genetic information seems to favour involvement of vascular mechanism

SUBMITTER: van den Maagdenberg AMJM 

PROVIDER: S-EPMC6734558 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature