Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.

ABSTRACT:

Background

Approximately 4% of colorectal cancer (CRC) patients have at least two simultaneous cancers in the colon. Due to the shared environment, these synchronous CRCs (SCRCs) provide a unique setting to study colorectal carcinogenesis. Understanding whether these tumours are genetically similar or distinct is essential when designing therapeutic approaches.

Methods

We performed exome sequencing of 47 primary cancers and corresponding normal samples from 23 patients. Additionally, we carried out a comprehensive mutational signature analysis to assess whether tumours had undergone similar mutational processes and the first immune cell score analysis (IS) of SCRC to analyse the interplay between immune cell invasion and mutation profile in both lesions of an individual.

SUBMITTER: Hanninen UA 

PROVIDER: S-EPMC6734647 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature