ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancers (TNBC) are poor-prognosis tumours candidate to chemotherapy as only systemic treatment. We previously found that PRICKLE1, a prometastatic protein involved in planar cell polarity, is upregulated in TNBC. We investigated the protein complex associated with PRICKLE1 in TNBC to identify proteins possibly involved in metastatic dissemination, which might provide new prognostic and/or therapeutic targets.

Methods

We used a proteomic approach to identify protein complexes associated with PRICKLE1. The mRNA expression levels of the corresponding genes were assessed in 8982 patients with invasive primary breast cancer. We then characterised the molecular interaction between PRICKLE1 and the guanine nucleotide exchange factor ECT2. Finally,

SUBMITTER: Daulat AM 

PROVIDER: S-EPMC6734648 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature