Preoperative chemotherapy and radiotherapy concomitant to cetuximab in resectable stage IIIB NSCLC: a multicentre phase 2 trial (SAKK 16/08).

ABSTRACT:

Background

Neoadjuvant chemotherapy (CT) followed by radiotherapy (RT) and surgery showed a median survival of 28.7 months in resectable stage IIIB non-small-cell lung cancer (NSCLC) patients (pts). Here, we evaluate the impact of concomitant cetuximab to the same neoadjuvant chemo-radiotherapy (CRT) in selected patients (pts) with NSCLC, stage IIIB.

Methods

Resectable stage IIIB NSCLC received three cycles of CT (cisplatin 100 mg/m² and docetaxel 85 mg/m² d1, q3w) followed by RT (44 Gy in 22 fractions) with concomitant cetuximab (250 mg/m², q1w) and subsequent surgery. The primary endpoint was 1-year progression-free survival (PFS).

Results

Sixty-nine pts were included in the trial. Fifty-seven (83%) pts underwent surgery, with comple

SUBMITTER: Curioni-Fontecedro A 

PROVIDER: S-EPMC6734655 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature