Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents.

ABSTRACT: Exogenous chemical exchange saturation transfer (CEST) contrast agents such as glucose or 2-deoxy-d-glucose (2-DG) have shown high sensitivities and significant potential for monitoring glucose uptake in tumors with MRI. Here, we show that liposome encapsulation of such agents can be exploited to enhance the CEST signal by reducing the overall apparent exchange rate. We have developed a concise analytical model to describe the liposomal contrast dependence on several parameters such as pH, temperature, irradiation amplitude, and intraliposomal water content. This is the first study in which a model has been constructed to measure the exchange properties of diamagnetic CEST agents encapsulated inside liposomes. Experimentally measured exchange rates of glucose and 2-DG in the liposomal syst

SUBMITTER: Demetriou E 

PROVIDER: S-EPMC6734798 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature