The Superficial White Matter in Autism and Its Role in Connectivity Anomalies and Symptom Severity.

ABSTRACT: In autism spectrum disorders (ASDs), the majority of neuroimaging studies have focused on the analysis of cortical morphology. White matter changes remain less understood, particularly their association to cortical structure and function. Here, we focused on region that has gained only little attention in ASD neuroimaging: the superficial white matter (SWM) immediately beneath the cortical interface, a compartment playing a prominent role in corticogenesis that incorporates long- and short-range fibers implicated in corticocortical connectivity. Studying a multicentric dataset of ASD and neurotypical controls, we harnessed surface-based techniques to aggregate microstructural SWM diffusion features. Multivariate analysis revealed SWM anomalies in ASD compared with controls in medial pariet

SUBMITTER: Hong SJ 

PROVIDER: S-EPMC6735258 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature