¹¹¹In-Pentetreotide Scintigraphy Versus ⁶⁸Ga-DOTATATE PET: Impact on Krenning Scores and Effect of Tumor Burden.

ABSTRACT: Eligibility for somatostatin receptor (SSTR) radionuclide therapy uses the qualitative Krenning score based on ¹¹¹In-pentetreotide planar scintigraphy as was performed in the NETTER-1 trial. The purpose of this study was to determine the effect of using SSTR PET-based Krenning score in comparison to ¹¹¹In-pentetreotide. Methods: This was a post hoc head-to-head comparison of ⁶⁸Ga-DOTATATE-based and ¹¹¹In-pentetreotide-based Krenning scores in 150 patients included in a prospective phase 2 study (NCT01967537). Patients were imaged using ⁶⁸Ga-DOTATATE PET/CT, ¹¹¹In-pentetreotide planar scintigraphy, and SPECT/CT within 1 wk. SSTR ligand uptake was graded using the Krenning score independently by 3 readers. Results:</

SUBMITTER: Hope TA 

PROVIDER: S-EPMC6735279 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature