Galectin 3 protects from cisplatin-induced acute kidney injury by promoting TLR-2-dependent activation of IDO1/Kynurenine pathway in renal DCs.
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ABSTRACT:
SUBMITTER: Volarevic V
PROVIDER: S-EPMC6735380 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Galectin 3 protects from cisplatin-induced acute kidney injury by promoting TLR-2-dependent activation of IDO1/Kynurenine pathway in renal DCs.
Volarevic Vladislav V Markovic Bojana Simovic BS Jankovic Marina Gazdic MG Djokovic Bojana B Jovicic Nemanja N Harrell C Randall CR Fellabaum Crissy C Djonov Valentin V Arsenijevic Nebojsa N Lukic Miodrag L ML
Theranostics 20190814 20
Strategies targeting cross-talk between immunosuppressive renal dendritic cells (DCs) and T regulatory cells (Tregs) may be effective in treating cisplatin (CDDP)-induced acute kidney injury (AKI). Galectin 3 (Gal-3), expressed on renal DCs, is known as a crucial regulator of immune response in the kidneys. In this study, we investigated the role of Gal-3 for DCs-mediated expansion of Tregs in the attenuation of CDDP-induced AKI. <b>Methods</b>: AKI was induced in CDDP-treated wild type (WT) C57 ...[more]
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