Phenotypic Spectrum of Pentosan Polysulfate Sodium-Associated Maculopathy: A Multicenter Study.

ABSTRACT:

Importance

A unique pigmentary maculopathy was recently described in 6 patients with long-term exposure to pentosan polysulfate sodium (PPS), a long-standing oral therapy for interstitial cystitis.

Objective

To characterize the exposure characteristics and clinical manifestations of PPS-associated maculopathy.

Design, setting, and participants

In this multi-institutional case series, medical records of patients who exhibited the characteristic maculopathy in the setting of prior PPS exposure were retrospectively reviewed. Data were collected from August 1, 2012, to October 1, 2018, and data were analyzed from October 2018 to January 2019.

Main outcomes and measures

Drug exposure, visual acuity, and retinal imaging characteristics.

Results

Of the 35 inclu

SUBMITTER: Hanif AM 

PROVIDER: S-EPMC6735406 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature