Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.

ABSTRACT:

Context

Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance.

Objective

To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns.

Design

Cross-sectional, observational study.

Setting

Hyperglycemia and Adverse Pregnancy Outcome study.

Participants

One thousand six hundred multiethnic mother-newborn pairs.

Main outcome measure

Cord blood C-peptide, birthweight, and newborn sum of skinfolds.

Results

Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associa

SUBMITTER: Kadakia R 

PROVIDER: S-EPMC6735762 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature