Primary human testicular PDGFRα+ cells are multipotent and can be differentiated into cells with Leydig cell characteristics in vitro.
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ABSTRACT:
SUBMITTER: Eliveld J
PROVIDER: S-EPMC6735802 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Primary human testicular PDGFRα+ cells are multipotent and can be differentiated into cells with Leydig cell characteristics in vitro.
Eliveld J J van den Berg E A EA Chikhovskaya J V JV van Daalen S K M SKM de Winter-Korver C M CM van der Veen F F Repping S S Teerds K K van Pelt A M M AMM
Human reproduction (Oxford, England) 20190901 9
<h4>Study question</h4>Is it possible to differentiate primary human testicular platelet-derived growth factor receptor alpha positive (PDGFRα+) cells into functional Leydig cells?<h4>Summary answer</h4>Although human testicular PDGFRα+ cells are multipotent and are capable of differentiating into steroidogenic cells with Leydig cell characteristics, they are not able to produce testosterone after differentiation.<h4>What is known already</h4>In rodents, stem Leydig cells (SLCs) that have been i ...[more]
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