Interactions of the DASH Diet with the Renin-Angiotensin-Aldosterone System.

ABSTRACT:

Background

The Dietary Approaches to Stop Hypertension (DASH) diet is widely recommended to lower blood pressure, but its mechanisms of action are unclear. Lines of evidence suggest an interaction with the renin-angiotensin-aldosterone system (RAAS).

Objective

We conducted a randomized, controlled, cross-over feeding trial to test RAAS-related mechanisms underlying the DASH diet in patients with isolated systolic hypertension.

Methods

Participants entered a 1-wk run-in period on a control (CON) diet and then consumed the DASH or CON diets for 4 wk each in randomized sequence. Calorie content was controlled to maintain weight, and sodium intake was set at 3 g daily. After each diet, participants had hormonal and hemodynamic assessments obtained at baseline, in response

SUBMITTER: Maris SA 

PROVIDER: S-EPMC6735835 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature