Prospective, Real-time Metagenomic Sequencing During Norovirus Outbreak Reveals Discrete Transmission Clusters.

ABSTRACT:

Background

Norovirus outbreaks in hospital settings are a common challenge for infection prevention teams. Given the high burden of norovirus in most communities, it can be difficult to distinguish between ongoing in-hospital transmission of the virus and new introductions from the community, and it is challenging to understand the long-term impacts of outbreak-associated viruses within medical systems using traditional epidemiological approaches alone.

Methods

Real-time metagenomic sequencing during an ongoing norovirus outbreak associated with a retrospective cohort study.

Results

We describe a hospital-associated norovirus outbreak that affected 13 patients over a 27-day period in a large, tertiary, pediatric hospital. The outbreak was chronologically associated wi

SUBMITTER: Casto AM 

PROVIDER: S-EPMC6735836 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature