A network of networks approach for modeling interconnected brain tissue-specific networks.

ABSTRACT:

Motivation

Recent sequence-based analyses have identified a lot of gene variants that may contribute to neurogenetic disorders such as autism spectrum disorder and schizophrenia. Several state-of-the-art network-based analyses have been proposed for mechanical understanding of genetic variants in neurogenetic disorders. However, these methods were mainly designed for modeling and analyzing single networks that do not interact with or depend on other networks, and thus cannot capture the properties between interdependent systems in brain-specific tissues, circuits and regions which are connected each other and affect behavior and cognitive processes.

Results

We introduce a novel and efficient framework, called a 'Network of Networks' approach, to infer the interconnectivity s

SUBMITTER: Kawakubo H 

PROVIDER: S-EPMC6735868 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature