Benchmark problems for dynamic modeling of intracellular processes.

ABSTRACT:

Motivation

Dynamic models are used in systems biology to study and understand cellular processes like gene regulation or signal transduction. Frequently, ordinary differential equation (ODE) models are used to model the time and dose dependency of the abundances of molecular compounds as well as interactions and translocations. A multitude of computational approaches, e.g. for parameter estimation or uncertainty analysis have been developed within recent years. However, many of these approaches lack proper testing in application settings because a comprehensive set of benchmark problems is yet missing.

Results

We present a collection of 20 benchmark problems in order to evaluate new and existing methodologies, where an ODE model with corresponding experimental data is referr

SUBMITTER: Hass H 

PROVIDER: S-EPMC6735869 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature