Nonspecific Low Back Pain: Inflammatory Profiles of Patients With Acute and Chronic Pain.

ABSTRACT:

Background

The pathogenesis of low back pain (LBP) remains unclear. However, recent studies suggest that the inflammatory response may be inherent in spinal pain. The purpose of this study was to discern inflammatory profiles in patients with nonspecific acute and chronic LBP in relation to those in asymptomatic individuals.

Materials and methods

Peripheral blood samples were obtained from asymptomatic controls and patients with nonspecific acute and chronic LBP reporting a minimum pain score of 3 on a 10-point Visual Analogue Scale (VAS). The levels of in vitro production of proinflammatory (tumor necrosis factor α [TNFα], interleukin [IL] 1β, IL-6, IL-2, interferon γ) and anti-inflammatory (IL-1 receptor antagonist, soluble receptors of TNF2, and IL-10) mediators were dete

SUBMITTER: Teodorczyk-Injeyan JA 

PROVIDER: S-EPMC6735949 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature