AllerCatPro-prediction of protein allergenicity potential from the protein sequence.

ABSTRACT:

Motivation

Due to the risk of inducing an immediate Type I (IgE-mediated) allergic response, proteins intended for use in consumer products must be investigated for their allergenic potential before introduction into the marketplace. The FAO/WHO guidelines for computational assessment of allergenic potential of proteins based on short peptide hits and linear sequence window identity thresholds misclassify many proteins as allergens.

Results

We developed AllerCatPro which predicts the allergenic potential of proteins based on similarity of their 3D protein structure as well as their amino acid sequence compared with a data set of known protein allergens comprising of 4180 unique allergenic protein sequences derived from the union of the major databases Food Allergy Research a

SUBMITTER: Maurer-Stroh S 

PROVIDER: S-EPMC6736023 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature