Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Early Puberty.

ABSTRACT:

Context

Obesity is known to impact reproductive function in adults, but little is known about its effects on reproductive hormones during puberty.

Objective

To assess sex differences in effects of obesity on reproductive hormones and their relation to insulin sensitivity and secretion.

Design

Cross-sectional study including anthropometrics, serum and urine reproductive hormone concentrations, and intravenous glucose tolerance testing (IVGTT) to assess acute insulin response to glucose (AIRg), and insulin sensitivity (Si).

Setting

Outpatient academic clinical research center.

Patients

Girls (52%) and boys (48%) who were normal weight (NW; n = 51, BMI-Z score = -0.11 ± 0.77, age = 11.5 ± 1.7 years) and obese (n = 53, BMI-Z score = 2.22 ± 0.33, age = 10.9 ±

SUBMITTER: Nokoff N 

PROVIDER: S-EPMC6736047 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature