Epigenetic transgenerational inheritance of testis pathology and Sertoli cell epimutations: generational origins of male infertility.

ABSTRACT: Male reproductive health has been in decline for decades with dropping sperm counts and increasing infertility, which has created a significant societal and economic burden. Between the 1970s and now, a general decline of over 50% in sperm concentration has been observed in the population. Environmental toxicant-induced epigenetic transgenerational inheritance has been shown to affect testis pathology and sperm count. Sertoli cells have an essential role in spermatogenesis by providing physical and nutritional support for developing germ cells. The current study was designed to further investigate the transgenerational epigenetic changes in the rat Sertoli cell epigenome and transcriptome that are associated with the onset of testis disease. Gestating female F0 generation rats were transie

SUBMITTER: Sadler-Riggleman I 

PROVIDER: S-EPMC6736068 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature