Healthy diet is associated with gene expression in blood: the Framingham Heart Study.

ABSTRACT:

Background

Genes in metabolic and nutrient signaling pathways play important roles in lifespan in model organisms and human longevity.

Objective

The aim of this study was to examine the relation of a quantitative measure of healthy diet to gene expression in a community-based cohort.

Methods

We used the 2015 Dietary Guidelines for Americans Adherence Index (DGAI) score to quantify key dietary recommendations of an overall healthy diet. Our current analyses included 2220 Offspring participants (mean age 66 ± 9 y, 55.4% women) and 2941 Third-Generation participants (mean age 46 ± 9 y, 54.5% women) from the Framingham Heart Study. Gene expression was profiled in blood through the use of the Affymetrix Human Exon 1.0 ST Array. We conducted a transcriptome-wide association

SUBMITTER: Lin H 

PROVIDER: S-EPMC6736078 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature